Fig. 4: TGFβ induces fibroblast activation in alveolosphere model. | Communications Biology

Fig. 4: TGFβ induces fibroblast activation in alveolosphere model.

From: Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids

Fig. 4

A UMAP plots of mesenchymal cell clusters on day 3 (top) and cell cycle phases (bottom, G1: green, G2M: pink, M: purple). Plot contains all 3 treatment groups (DMSO, 10 µM DB-11-BE87, 10 µM QA-92-TQ17). B Expression of marker genes in mesenchymal cell clusters from (A). C UMAP plot of integrated mesenchymal cells from day 1 (red) and day 3 (teal). D UMAP plot of mesenchymal subclusters from (C) colored by cell type labels. E RNA velocity vectors projected over UMAP plot of mesenchymal cells from day 3 samples. Cells are colored by cell type labels. F UMAP plots of mesenchymal cells from day 3 samples, colored by either gene expression (Cthrc1) or pathway activity scores (TGF-β pathway, WNT signaling, and ECM pathway).

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