Fig. 3: Adapting a coarse grained model to experiments. | Communications Biology

Fig. 3: Adapting a coarse grained model to experiments.

From: Long-term potentiation-induced changes in actin dynamics and spine geometry persist on the timescale of the synaptic tag

Fig. 3

A Dynamic pool is assumed to decay exponentially after a fast, initial increase during LTP. This increase takes place at time Δt before the end of the cLTP protocol. B Stable pool is assumed to be a low-pass filtered version of the dynamic pool. C The resulting fraction of stable F-actin exhibits an overshoot later than the stable pool itself. D Weighted mean squared error (MSE) for combinations of τd and τu. Parameters of the best-fitting model (star) are used in (A-C). E Best matching time shift Δt and F best matching basal stable pool fraction fb that were used to calculate errors in (D).

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