Fig. 1: Mice surviving sepsis exhibit an altered immune phenotype in vivo. | Communications Biology

Fig. 1: Mice surviving sepsis exhibit an altered immune phenotype in vivo.

From: Sepsis restructures the mitochondrial calcium uniporter complex in the lymphoid tissues of mice and humans

Fig. 1

C57Bl/6 mice underwent cecal ligation and puncture (CLP) with best clinical practices or sham surgery with best clinical practices. At day 7 or 30, mice were euthanized, blood was collected, and plasma cytokines concentrations assayed by ELISA. At day 30, a nested, parallel cohort was administered intratracheally either LPS (3 mg/kg; i.t.) or equivolume 0.9% saline (NS). After 24 h, mice were euthanized, blood was collected, and plasma cytokines concentrations assayed by ELISA. A TNFα, IL-6, and IL-10 plasma concentrations – basal at day 7 and day 30. B TNFα, IL-6, and IL-10 plasma concentrations – endotoxemia. Sham (n = 5, 7 mice) CLP (n = 8, 19 mice). Wilcoxon rank sum. bar = median.

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