Fig. 5: Lipidomics analysis of 18-month-old ΔLYST-B6 cerebellum and forebrain. | Communications Biology

Fig. 5: Lipidomics analysis of 18-month-old ΔLYST-B6 cerebellum and forebrain.

From: A murine model lacking Lyst recapitulates Chediak-Higashi syndrome with an earlier-onset neurodegenerative phenotype

Fig. 5

a Partial least squares-discriminant analysis (PLS-DA) of variation in negative ion lipidomics in the cerebellum and forebrain of WT (n = 3) and ΔLYST-B6 mice (n = 3). b PLS-DA of variation in positive ion lipidomics in the cerebellum and forebrain of WT (purple) and ΔLYST-B6 (grey) mice. c–f Heatmaps showing expression of lipids of in the brains of ΔLYST-B6 and WT mice. Red represents of over-expression of the lipid or lipid class, while blue shows under-expression. c Positive ion lipids in the forebrain. d Positive ion lipids in the cerebellum. e Negative ion lipids in the forebrain. f Negative ion lipids in the cerebellum. WT, wild-type; ΔLYST-B6, Lyst homozygous knockout (C57BL/6J background).

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