Fig. 6: RNA sequencing of 3- and 18-month-old ΔLYST-B6 cerebellum and forebrain. | Communications Biology

Fig. 6: RNA sequencing of 3- and 18-month-old ΔLYST-B6 cerebellum and forebrain.

From: A murine model lacking Lyst recapitulates Chediak-Higashi syndrome with an earlier-onset neurodegenerative phenotype

Fig. 6

Principal component analysis (PCA) of variation in 3-month-old forebrain (a), 18-month-old forebrain (b), 3-month-old cerebellum (c), and 18-month-old cerebellum (d). WT (n = 3) and ΔLYST-B6 mice (n = 3). Volcano plots showing differential expression of genes in 3- and 18-month-old cerebellum and forebrain of ΔLYST-B6 mice. Red represents significantly upregulated genes, while blue shows significantly downregulated genes. Fold change is calculated as ΔLYST-B6/WT. This analysis was performed in 3-month-old forebrain (e), 18-month-old forebrain (f), 3-month-old cerebellum (g), and 18-month-old cerebellum (h). Heatmaps showing differential expression of genes in the forebrain and cerebellum of WT (purple) and ΔLYST-B6 (grey) mice at 3- and 18-months old. Red represents significantly upregulated genes and blue represents significantly downregulated genes. This analysis was performed in 3-month-old forebrain (i), 18-month-old forebrain (j), 3-month-old cerebellum (k), and 18-month-old cerebellum (l). WT wild-type, ΔLYST-B6, Lyst homozygous knockout (C57BL/6 J background).

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