Table 2 Top 5 differentially-expressed lipid classes in the forebrain and cerebellum of 18-month-old WT and ΔLYST-B6 mice

From: A murine model lacking Lyst recapitulates Chediak-Higashi syndrome with an earlier-onset neurodegenerative phenotype

Brain Region

Lipid Class

Ion

Log2(Fold Change)

P-value

Forebrain

BiotinylPE

Negative

−2.30

6.87E−5

Forebrain

Hex1Cer

Negative

−1.09

1.46E−4

Forebrain

LPE

Negative

0.59

6.31E−4

Forebrain

LPG

Negative

1.24

8.12E−4

Forebrain

Hex2Cer

Negative

−1.38

1.60E−3

Cerebellum

TG

Positive

1.20

3.78E−14

Cerebellum

BiotinylPE

Negative

2.30

3.50E−7

Cerebellum

OAHFA

Negative

−1.84

6.30E−6

Cerebellum

PS

Negative

0.65

3.09E−4

Cerebellum

Hex1Cer

Positive

−0.66

7.26E−4

  1. BiotinylPE Biotinylated phosphatidylethanolamine, Hex1Cer hexosylceramide, LPE lysophosphatidylethanolamine, LPG lysophosphatidyl-glycerol, Hex2Cer dihexosylceramide, TG triglyceride, OAHFA (O-acyl)-ω- hydroxy fatty acid, PS phosphatidylserine, MG monoradylglycerolipid, Cer ceramide, DG diacylglycerols.
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