Fig. 3: Longitudinal Sample Analysis of Viral Mutations using SS in the HIV-1 env region. | Communications Biology

Fig. 3: Longitudinal Sample Analysis of Viral Mutations using SS in the HIV-1 env region.

From: Unique molecular signatures in rebound viruses from antiretroviral drug and CRISPR-treated HIV-1-infected humanized mice

Fig. 3

A Mapping of nucleotide variants detected in the env region sequences from the five selected HIV-1NL4-3 animal groups (identified by the mouse ID on the right axis) at pre-ART (PRE), post-ART/pre-CRISPR (MID), and endpoints (END) (shown on the left axis). Individual nucleotide substitutions were depicted with distinct colors per the key below the graph. B The frequency of env variants at pre-ART (n = 5), post-ART/pre-CRISPR (n = 3), and endpoint (n = 5) was compared and analyzed using one-way ANOVA. Individual animals were represented with unique color-coded dots and lines (3139, 3171, 3182, 4356, and 4358). A significant increase in mutation frequency was observed (p = 0.019). C Donut charts illustrate the proportion of env nucleotide variants from individual mice at the specified time points, with pre-ART, post-ART/pre-CRISPR, and endpoint phases denoted by blue, red, and orange, respectively.

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