Table 1 Correlation analysis of HIV-1NL4_3 Mutation Frequency with endpoint plasma viral load

From: Unique molecular signatures in rebound viruses from antiretroviral drug and CRISPR-treated HIV-1-infected humanized mice

Mutation Frequency (HIV-1NL4-3 group

Spearman r

95% (CI)

p value

Mutation Frequency in gag

−0.2067

−0.6038 to 0.2726

0.382

Mutation Freq in pol

−0.5879

−0.8271 to -0.1684

0.008**

Mutation Freq in env

0.1657

−0.3115 to 0.5761

0.485

  1. Correlation Analysis. The HIV-1NL4_3 nucleotide variant frequency (calculated as the total number of variants divided by the total number of nucleotides sequenced per sample) detected at the endpoint in the gag, pol, and env regions was correlated with the endpoint plasma viral load. The correlations were determined using Spearman’s rank test. The correlation coefficient r value and p-values were calculated and shown, with a p-value less than 0.05 considered significant.
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