Table 3 DRAMs detected in RT/PR/IN using Next Generation Sequencing (NGS)
Mutations | Sample ID and (Group) | Classification | Summary |
|---|---|---|---|
E138EK Frequency: E: 97%, K: 3.1%, Coverage:27,891 | 3169 (LA ART Group) | NNRTI Mutations | A mutation selected in a high proportion of persons receiving RPV. It reduces RPV susceptibility 2 to 3-fold. In combination with K101E or M184I, it is sufficient to cause VF on a first-line RPV-containing regimen. |
H221HY Frequency: H: 96%, Y: 4.1% Coverage:27,941 | 3169 (LA ART Group) | NNRTI Accessory Mutations | An accessory mutation selected primarily by NVP, RPV, and DOR |
K101KER Frequency: K: 73%, E: 14%, R: 13% Coverage: 33,086 | 3181 (LA ART Group) | NNRTI Accessory Mutations | An accessory mutation that confers intermediate resistance to NVP and RPV This virus is predicted to have intermediate-level reduced susceptibility to RPV. |
V75VI Frequency: V: 94%, I: 5.1% Coverage: 26,696 | 3182 (LA ART Group) | NRTI Accessory Mutations | An accessory mutation that often occurs in combination with the multi-NRTI resistance mutation Q151M. When it occurs alone, its clinical significance is uncertain. |
