Fig. 1: Single cell analysis of RPE and melanocytes from the murine eye. | Communications Biology

Fig. 1: Single cell analysis of RPE and melanocytes from the murine eye.

From: Melanocytes and photosensory organs share a common ancestry that illuminates the origins of the neural crest

Fig. 1

a Schematic representation of a vertebrate eye with uveal melanocytes and RPE layer. Created with BioRender.com. Licensed content used with permission. b Clustering of single-cell transcriptomic data adapted from Lee et al., 2022. c UMAP visualizations of main melanocyte and RPE markers. d Dot plot of major marker genes for clusters in b. e, f UMAP (e) after re-clustering of melanocyte and RPE clusters from Lee et al. and differential expression of key genes (f). g STRING analysis of differentially expressed genes enriched in melanocytes or RPE cells (the color code links genes to cell types). h, i GO terms enrichment of genes expressed in melanocytes (h) and RPE (i).

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