Fig. 4: The developmental timeline of RPE in comparison with ocular melanocyte gene expression programs. | Communications Biology

Fig. 4: The developmental timeline of RPE in comparison with ocular melanocyte gene expression programs.

From: Melanocytes and photosensory organs share a common ancestry that illuminates the origins of the neural crest

Fig. 4

a UMAP and clustering of early developing human RPE from Zheng et al., 2023. b Expression of the main RPE and melanocyte marker genes from the same dataset (as in a). c, d UMAP and clustering of later developmental stages of human RPE and melanocytes from Collin et al., 2022. e Dot plot showing expression of RPE-enriched and melanocyte-enriched genes across clusters and developmental stages (PCW - post conception week). f, g Analysis of melanocyte- and RPE-enriched genes in mouse spatial transcriptomics data from Chen et al., 2021.

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