Fig. 1: Differential secreted protein analysis and network interactions in Biofilm exposed PBMCs. | Communications Biology

Fig. 1: Differential secreted protein analysis and network interactions in Biofilm exposed PBMCs.

From: Staphylococcus aureus biofilm-associated component PNAG stimulates the secretion of the immunomodulatory chemokine CXCL10 via Dectin-1 signaling

Fig. 1

A Volcano plot (-logq versus logFC) showing the difference in the abundance of secreted proteins in PBMCs exposed to biofilms (right). Proteins with a twofold higher (logFC > 1) or lower (logFC < -1) abundance (indicated by the vertical black lines) and BH-corrected p values < 0.05 (indicated by the horizontal red lines) are highlighted (blue and orange, respectively). The significantly differentially abundant proteins were further explored for GO terms and KEGG pathway analysis and visualized. B Protein‒protein interaction (PPI) network of proteins differentially secreted by PBMCs upon exposure to biofilms (right). The gene-concept network depicts the linkages of genes and biological concepts (e.g., GO terms or KEGG pathways) as a network. The gene-concept network was constructed to visualize the most relevant nodes engaging in hubs. Edges confidence correlates with the strength of the PPI.

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