Fig. 5: Effects of Dectin-1 blockade and Syk inhibition on CXCL10 secretion by PBMCs. | Communications Biology

Fig. 5: Effects of Dectin-1 blockade and Syk inhibition on CXCL10 secretion by PBMCs.

From: Staphylococcus aureus biofilm-associated component PNAG stimulates the secretion of the immunomodulatory chemokine CXCL10 via Dectin-1 signaling

Fig. 5

A Secretion of CXCL10 with/without antibody blockade of Dectin-1 in PBMCs treated with PNAG or SpA. B Levels of secreted CXCL10 in PBMCs with/without inhibition of the protein tyrosine kinase SyK. The values are presented as the means and standard deviations (SDs) of three independent experiments. Asterisks indicate significant differences as p values * ≤0.05 ** ≤0.01 and *** ≤0.001. Abbreviations: AD1_PNAG or SpA: Antibody-blocked Dectin-1 PBMCs treated with PNAG or SpA, ASyK_: SyK inhibited PBMCs treated with PNAG or SpA, PNAG or SpA: PBMCs treated with PNAG or SpA.

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