Fig. 1: Change responses in transitional click trains.
From: EEG neural indicator of temporal integration in the human auditory brain with clinical implications
a Illustration of a regular click train (above) and an irregular click train (below), both comprising 0.2-ms pulses with specific ICI, where regular click trains maintain a constant ICI and the ICI of the irregular click train is randomized following a Gaussian distribution. b Setup of the transitional click train showing a regular transitional click train beginning with a 1 s regular click train at 4 ms ICI, transitioning into a 1-s regular click train at 4.06-ms ICI, denoted as Reg4-4.06, and an irregular group where regular click trains are replaced by irregular ones while keeping the average ICIs equal (standard deviation: μ/2, where μ is the mean ICI value), denoted as Irreg4-4.06, with the black pulse indicating the common pulse shared by both trains and the green dashed line marking the transition point. c Grand-averaged responses at POz to Reg4-4.06 (red) and Irreg4-4.06 (black) across 42 subjects from Session 1 of Experiment 2. Shaded areas around curves represent \(\pm\) standard error of the mean (SEM). Orange vertical dashed lines indicate onset, change, and offset of the stimulus, from left to right. The yellow vertical bars represent significant difference between the two conditions (p < 0.05, permutation test). d A magnified view from (c) focusing on the window from -200 to 400 ms relative to the change point in the transitional click train. e Scatterplots of the relative response magnitude (RM) of change responses during 74-251 ms after change for each subject under Reg4-4.06 and Irreg4-4.06, showing significantly larger change responses in the regular group compared to the irregular group (p < 0.001, two-tailed paired t-test). Topographic maps (top-left: Reg4-4.06; bottom-right: Irreg4-4.06) show RM distributions across the scalp, with dots indicating electrodes with significant change responses (p < 0.05, two-tailed one-sample t-test, FDR corrected). f Source reconstruction of change response. Color scale shows the relative difference in source power between Reg4-4.06 and Reg4-4 within [0, 300] ms window after change, averaged across 42 subjects. Only significant areas are colored (p < 0.05, cluster-based permutation test). g Similar to (f) but for Irreg4-4.06 and Irreg4-4, with no area with significant difference found.
