Fig. 3: Cervical and lumbar CSF-cNs mainly exhibit tonic AP firing while thoracic ones show single-spiking. | Communications Biology

Fig. 3: Cervical and lumbar CSF-cNs mainly exhibit tonic AP firing while thoracic ones show single-spiking.

From: Cerebrospinal fluid-contacting neurons are sensory neurons with uniform morphological and region-specific electrophysiological properties in the mouse spinal cord

Fig. 3

A Representative voltage traces for CSF-cNs recorded in the three regions of interest (A1, cervical (C); A2, thoracic (T) and A3, lumbar (L) from RMP (indicated below the traces). Variation in the membrane potential was elicited with DC current injection steps (–10, +10 and +30 pA for 500 and 250 ms in A1, A3 and A2, respectively) and upon positive current injections, CSF-cNs exhibit either single-spike (SP) or tonic (T) firing, Gray dashed lines indicate the 0 mV level. B Summary histogram for the proportion (in percent) of CSF-cNs showing either SP or T firing patterns at C, T and L levels (C: N = 10 for the number of animals, n = 21 for the sample size; T: N = 12, n = 23 and L: N = 9, n = 21). Fisher’s Exact test, p = 3.772 × 10−6 and post hoc pairwise comparisons using Wilcoxon rank sum test with continuity correction: C vs. T, p = 1.19 × 10−4; C vs. L, p = 0.6466 and T vs. L, p = 8.88 × 10−6).

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