Table 1 Intrinsic properties of CSF-cNs along the rostro-caudal central canal axis

From: Cerebrospinal fluid-contacting neurons are sensory neurons with uniform morphological and region-specific electrophysiological properties in the mouse spinal cord

Spinal Segment

Cervical (C)

Thoracic (T)

Lumbar (T)

Input resistance

Rm

3.6 ± 2.1 GΩ

3.6 ± 1.9 GΩ

4.1 ± 12.1 GΩ

Kruskal-Wallis’s test: : χ2 = 5.5711; degree of freedom (df)=2; p = 0.0617

Post hoc pairwise Wilcoxon rank sum test: C vs. T, p = 0.826, ns; C vs. L, p = 0.069, ns & T vs. L, p = 0.069, ns

Membrane capacitance

Cm

5.6 ± 2.9 pF

5.0 ± 2.5 pF

6.2 ± 2.9 pF

Kruskal-Wallis’s test: χ2 = 25.722; df=2; p = 2.597.10-6

Post hoc pairwise Wilcoxon rank sum test: C vs. T, p = 0.0064, **; C vs. L, p = 0.0242, * & T vs. L, p = 1.3.10-6, ***

Membrane time constant

τm

92 ± 58 µs

86 ± 49 µs

90 ± 49 µs

Kruskal-Wallis’s test: χ2 = 3.8282; df = 2; p = 0.1475

Post hoc pairwise Wilcoxon rank sum test: C vs. T, p = 0.40, ns; C vs. L, p = 0.57, ns & T vs. L, p = 0.12, ns

N (animals), n (cells)

 

50, 227

65, 239

70, 193

Resting Membrane Potential

RMP

–46 ± 4 mV

–45 ± 6 mV

–61 ± 19 mV

Kruskal-Wallis’s test: χ2 = 18.368; df = 2; p = 1.027.10−5

Post hoc pairwise Wilcoxon rank sum test: C vs. T, p = 0.73535, ns; C vs. L, p = 0.00779, * & T vs. L, p = 0.00025, ***

N (animals), n (cells)

6, 20

10, 41

9, 64