Fig. 2: Exploration of treatment scheduling. | Communications Biology

Fig. 2: Exploration of treatment scheduling.

From: The role of environmentally mediated drug resistance in facilitating the spatial distribution of residual disease

Fig. 2

a Tumour burden for t ∈ [0, 240] days under no treatment, continuous treatment, and five intermitted treatment schedules (Ï„T = {10, 30, 50} days and Ï„H = 20 days). Individual realisations are shown, with 30 stochastic simulations conducted for each treatment regime. Reduction in tumour burden is observed as the length of the treatment period Ï„T of intermittent treatment increases. Continuous treatment initially displays a very good response to treatment, followed by EMDR-driven relapse. b–h show spatial distribution and drug concentration at representative time points for a single simulation of the regime of interest. b Day 0, the initial condition for all simulations. c Day 51 of no treatment. d Day 181 of continuous treatment regime. e Day 150 of intermittent treatment (Ï„T = 10 days, Ï„H = 20 days) regime. f Day 100 of intermittent treatment (Ï„T = 30 days, Ï„H = 20 days) regime. g Day 150 of intermittent treatment (Ï„T = 50 days, Ï„H = 20 days) regime. h Day 181 of intermittent treatment (Ï„T = 50 days, Ï„H = 20 days) regime. Animations of the proliferation signal, spatial distribution and drug concentration for each treatment regime are available in Supplementary Information S.5.

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