Fig. 3: Quantification of treatment regime outcomes. | Communications Biology

Fig. 3: Quantification of treatment regime outcomes.

From: The role of environmentally mediated drug resistance in facilitating the spatial distribution of residual disease

Fig. 3

a Cumulative days of drug delivery (measured as the sum of drug delivery days over 590 days of therapy) against relative tumour burden (measured as the sum of total cancer cell count over the t ∈ [0, 590] day window normalised to the continuous treatment case) for \({\tau }_{T}=\left\{10,20,30,40,50,60,70,80,90,100\right\}\) days and Ï„H = 20 days. For each schedule, averages over 30 simulations and 95% confidence intervals are shown. The star indicates reference measures for continuous treatment. As Ï„T is increased, relative tumour burden initially decreases and cumulative days of drug delivery increases, but from Ï„T = 50 days, the relative tumour burden increases. b The inset zooms in on measures for schedules with Ï„T ≥ 40 days. The treatment regime Ï„T = 50 days, Ï„H = 20 days is chosen for further analysis.

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