Fig. 4: Exploration of spatial attributes of EMDR.
a Timecourse of a single representative simulation of treatment schedule τT = 50 and τH = 20 over 590 days. Drug concentration mean field value; cancer cell populations; and activated stroma cell populations. b Spatial distribution of cells at 245, 315 and 385 days, corresponding to lowest total cancer cell population in treatment cycles away from the initial transient (corresponding time points are indicated in a). c, d Longitudinal occupancy of cancer and stroma, respectively, in the domain for t ∈ [150, 590] days (discarding transient) over 30 simulations. Occupancy is measured as fraction of time a lattice location in the domain is occupied by the cell type of interest. e Distributions of average number of cancer cell neighbours of cancer cells and activated stroma in the activation window over the same 30 simulations in (c, d) (discarding transient) with standard error shown. Here the activation window is the last 60% of the 50 days treatment window. Animations of the spatial distribution, proliferation signal and drug concentrations for treatment regime τT = 50 days, τH = 20 days are available in Supplementary Information S.5.
