Fig. 7: Targeted drug spatio-temporal dynamics over a treatment cycle.
Drug concentration, d, for the third treatment cycle (drug delivery + holiday period) with yellow highlight for locations where d ≥ hr. Representative eradication (E), survival (S) and persistence (P) niches are the same as in Fig. 5. a Drug concentration in the middle of the treatment period. The survival niche has a larger fraction of above-threshold locations. The eradication niche has a very low fraction of above-threshold locations and the persistence niche has no locations above the threshold. b Drug concentration near the end of the delivery period. Above-threshold locations now cover the entirety of the survival niche, and a large fraction of the eradication niche. There is a very small fraction of locations above the threshold in the persistence niche.
