Fig. 2: Erection was impaired in Uox-KO rats from 20 weeks. | Communications Biology

Fig. 2: Erection was impaired in Uox-KO rats from 20 weeks.

From: Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

Fig. 2

A Schematic diagram of hyperuricemia model construction using Uox-KO SD rats and the timepoint of the erection function test. Wk weeks. B The line chart of serum UA levels of Uox-KO and WT rats at 16, 20, 30, and 43 weeks was analyzed by the two-tailed unpaired t-test at each timepoint. n = 5 rats per group. Mean ± SD. C–F Representative images of intracavernous pressure (ICP) at 16, 20, 30, and 43 weeks Uox-KO and WT rats. G, H Dot plots of Max ICP/MAP and AUC at 16, 20, 30, and 43 weeks Uox-KO (n = 5) and WT (n = 6) rats were analyzed by the two-tailed unpaired t-test at each time point. Bars correspond to Mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. Panel a images created in BioRender; Wencan, C. (2025), https://BioRender.com/6xs09se.

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