Fig. 3: HUA enhanced corpus cavernosum smooth muscle contractility. | Communications Biology

Fig. 3: HUA enhanced corpus cavernosum smooth muscle contractility.

From: Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

Fig. 3

A Representative Masson staining images of the cavernous artery. Scale bars, 100 μm. B–D The histogram of vessel wall thickness (mm), lumen diameter (mm), and the ratio of wall thickness to lumen diameter (%). n = 3 corpus cavernosum sections from rats per group. E Schematic diagram of cell contraction assay proceeding from cell mixture to generate the polymerization gel, stressing, treatment, and release. F Cell contraction assay showing CCSMC contraction induced by high uric acid (450 μM) or control (extra 0 μM uric acid) with or without SNP (0.1 mM). The digital gel size change (contraction index) images were taken at 0 and 3 days. G The histogram of the gel area ratio of day 3 to day 0. H Representative image of CCSMC stained by Phalloidin-FITC (Green). Scale bars: 25 μm. I The histogram of relative cell surface area (%). n = 3 independent biological replicates in F-I. Bars correspond to Mean ± SD. *P < 0.05, ***P < 0.001 analyzed by the two-tailed unpaired t-test.

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