Fig. 1: Model and genetic background shape MSCNV. | Communications Biology

Fig. 1: Model and genetic background shape MSCNV.

From: Genetic background and oncogenic driver determines the genomic evolution and transcriptomics of mammary tumor metastasis

Fig. 1

a Schematic overview of mouse models, tissues collected, and analyses performed in this study. Histograms showing b the average percentage of the genome and c the average number of regions with CNV with standard deviation (SD), PT (blue), and lung mets (red). d Dot plot of individual CNV region lengths from aggregate data (the average indicated by black line). e Multivariate bubble plot showing average CNV number and aggregate total number of genes with CNV for PT (squares) and lung met (circles) from each model, with bubble size corresponding to CNV region size. Total number (black) of regions (f) and genes (g) with significant CNV gain (dark purple) and loss (light purple) in MSCNV. h Dot plot showing individual CNV region lengths from MSCNV (the average indicated by red line). i Multivariate bubble plot showing average CNV number and aggregate total number of genes with CNV for MSCNV (circles) from each model, with bubble size corresponding to CNV region size. j Histogram showing the average % of the genome and k average number of regions with CNV with SD, PT (blue), and lung mets (red). l Dot plot showing individual CNV region lengths from aggregate data with all animals per model combined (the average indicated by a line). m Multivariate bubble plot showing average CNV number and aggregate total number of genes with CNV for PT (squares) and lung met (circles) from each model, with bubble size corresponding to CNV region size. n Total number (black) of regions and o genes with significant CNV gain (dark purple) and loss (light purple) in Lung mets compared to PT. p Dot plot showing individual CNV region lengths from MSCNV (the average indicated by red line). q Multivariate bubble plot showing average CNV number and aggregate total number of genes with CNV for MSCNV (circles) from each model, with bubble size corresponding to CNV region size. Significance determined by Kruskal–Wallis test (d, h, l, p) or unpaired t test (b, c, j, k). *(p < 0.05), **(p < 0.01), ***(p < 0.001) ****(p < 0.0001), $ = significantly different from 6 groups, # = significantly different from 5 groups, ø = significantly different from 4 groups. Fig. 1a was generated using BioRender.

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