Fig. 4: MSCNV does not significantly impact metastasis-specific gene expression. | Communications Biology

Fig. 4: MSCNV does not significantly impact metastasis-specific gene expression.

From: Genetic background and oncogenic driver determines the genomic evolution and transcriptomics of mammary tumor metastasis

Fig. 4

a Histogram of the percentage of genes with MSCNV that are not expressed (blue), expressed in lung mets with no change from PT (pink), and differentially expressed in lung mets compared to PTs (red). Numbers listed before each model name represent the MSCNV gene set size. Histograms showing the percentage of genes with MSCNV-gain (b) or MSCNV-loss (c) that had significant up regulation (green) or down regulation (yellow) in lung mets compared to PTs. Paired volcano plots for the MSGE of genes within regions of MSCNV gain or loss for each FVB driver model (d–g) and PyMT-F1 model (h–n).

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