Fig. 6: CD39+ Tregs have a stronger immunosuppressive function in IMN patients and is associated with the fibrosis process.
From: Multi-omics insights of immune cells in the risk and prognosis of idiopathic membranous nephropathy
A Flow cytometry sorting of CD39+ Treg cells. B Boxplots showing the IL-10 secretion concentration (pg/ml) of CD39+ Tregs in IMN (blue) patients and healthy donors (red). The error bars represent the error margins. C Scatter plot showing the Spearman correlation between the CD39+ Tregs signature score and the FME score in patients with MN of ERCB dataset. D Scatter plot showing the Spearman correlation between the CD39+ Tregs signature score and the FME score in patients with IMN of NEPTUNE dataset. E Stacked bar plot showing the CR ratio in high-score and low-score groups (grouped by the median of FME score). F Kaplan–Meier analysis shows the CR rate of patients with the time spent on treatment, characterized by either low (blue) or high (yellow) FME scores. FME fibrotic microenvironment, MN membranous nephropathy, CR complete remission.
