Fig. 7: T2Dexo modulates intercellular communication networks.

A Circle plot showing the number of interactions among different cell types. The blue (orange) colored edges represent increased (decreased) signaling in T2Dexo compared to NDexo-PDOs. B Circle plot showing the differential interaction strength among different cell types. The blue (orange) colored edges represent increased (decreased) interaction strength in T2Dexo compared to NDexo-PDOs. C, D Circle plot displaying the number of interactions and the strength of interactions between cell types in NDexo-PDOs (C) and T2Dexo-PDOs (D). The number of lines represents the number of interactions, and the thickness of lines is proportional to the strength of the interactions. E Stacked bar plot showing the overall information flow of each significant signaling pathway (p < 0.01). The vertical dashed line indicates the position where the sample accounts for 50% of the overall information flow. Label color is determined by a significantly larger contribution from T2Dexo (blue) or NDexo-PDOs (orange). Pathways equally important in both datasets are labeled in black. P value determined by paired Wilcoxon test according to CellChat. Grey dots indicate pathways highlighted within the main text. F Scatter plot of dominant senders and receivers for NDexo (left) and T2Dexo-PDOs (right). G Scatter plot of the signaling changes associated with T cells in T2Dexo (blue) or NDexo-PDOs (orange). Shared pathways are labeled in gray. Collagen and laminin pathways have been removed from plot for ease of visualization.