Fig. 3: Intermittent food scarcity enhances tumor cell proliferation without affecting apoptotic markers.
From: Food insecurity impacts neuroblastoma pathogenesis in murine xenograft tumor models
A Ki67 expression was assessed in tumor sections by immunohistochemistry. Tumors from the food-insecure group exhibited significantly higher Ki67 positivity compared to controls, indicating increased proliferative activity. B PCNA expression, another marker of cellular proliferation, was elevated in tumors from food-insecure mice compared to controls, further supporting enhanced tumor growth under conditions of dietary stress. In contrast, cleaved PARP1 expression, a key apoptotic marker, remained unchanged between groups. (ns, p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).
