Fig. 2: Regulation of neuron differentiation by H3K4me1 and H3K27me3 and the effects of prenatal e-cig exposure. | Communications Biology

Fig. 2: Regulation of neuron differentiation by H3K4me1 and H3K27me3 and the effects of prenatal e-cig exposure.

From: Single-cell profiling of H3K4me1-H3K27me3 revealed bivalent regulation of abnormal neuronal development caused by prenatal e-cigarette vaporing

Fig. 2

A Volcano plot showing the differentially expressed genes (DEGs) between excitatory and inhibitory neurons in control PFC. Blue and red dots indicate the significant DEGs (|log2FoldChange| ≥1). B Heatmap showing the gene expression of the top 56 common DEGs between excitatory and inhibitory neurons identified from the H3K4me1 and H3K27me3 captures. C UpSet plot showing the number of DEGs identified in (A) that overlapped with the cluster DEGs induced by prenatal e-cigarette exposure. Peak coverage plots showing the signal distribution for H3K4me1 mark on Cnksr2, Gap43, and Dab1 (D) or H3K27me3 mark on Erbb4, Gabrb1, and Grik1(E) in excitatory and inhibitory neurons, respectively. F Relative gene expression levels (excitatory neuron vs. inhibitory neuron) of the six genes shown in (D, E). All data used in (A, B) were from the control PFC samples only to exclude the potential effect of prenatal e-cig exposure.

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