Fig. 1: Exposure to GlcSph and lyso-Gb3 at 20 ng/mL and 200 ng/mL significantly alters protein expression in the SH-Sy5y cell line.
From: Glucosylsphingosine affects mitochondrial function in a neuronal cell model
a Percent of significant (p < 0.05) protein changes of the total proteome by the lysolipid and dose. b The number of significantly up-/down-regulated proteins. Top 15 significantly affected cellular pathways by GlcSph at c 20 ng/mL and d 200 ng/mL. Circle radii represent the negative log10 of the pathway enrichment p-value < 0.05 and the proteins affected in the pathway. z-scores > 0 indicate activation while z-scores < 0 indicate deactivation of the pathway. e Significantly affected mitochondrial proteins by each lyso-lipid and dose. Source data are provided as a Supplementary Data file.
