Fig. 3: The effect of GlcSph on cellular stress in SH-Sy5y cells. | Communications Biology

Fig. 3: The effect of GlcSph on cellular stress in SH-Sy5y cells.

From: Glucosylsphingosine affects mitochondrial function in a neuronal cell model

Fig. 3

GlcSph exposure does not affect a adenylate energy charge (n = 4), and the activity of b cytosolic and c mitochondrial malate dehydrogenases (n = 6) in SH-Sy5y cells. d GlcSph exposure elicits an increase in the activity of glutathione reductase at 200 ng/mL (n = 9). DMSO was used as a vehicle control. Box plots show mean ±25% (boxes) and max. amd min. values (whiskers). Statistical significance was determined using a Kruskal–Wallis test with a Dunn’s post-hoc test. *p < 0.5. Source data are provided as a Supplementary Data file.

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