Fig. 8: Single cell RNA-sequence data of BNT162b2 vaccination in human. | Communications Biology

Fig. 8: Single cell RNA-sequence data of BNT162b2 vaccination in human.

From: SARS-CoV-2 vaccination during pregnancy enhances offspring hippocampal neurogenesis and working memory via IFN-γ–responsive microglia

Fig. 8

a UMAP representation of PBMCs subtypes identified by single-cell transcriptional profiling from Arunachalam et al.’s paper40. b Number of differentially expressed genes (DEGs) (absolute log2FC > 0.1 and adjust P < 0.05) at day 1, day 2 and day 7, compared with day 0. c IFN-gamma-related module score before vaccination (day 0) and after vaccination (day 1, day 2 and day 7) based on the Interferon-mediated Signaling Pathway (GO:0140888). d, e Heatmap for interferon regulatory factor 1 (IRF1) gene in cell types at each time point before and after SARS-CoV-2 vaccination. f, g Heatmap for STAT1 gene in cell types at each time point. h Gene-set enrichment analysis (GSEA) results of the significantly upregulated immune-related pathways in B cells, CD8 T cells and CD14 monocytes at day 1/day2 compared to day 0. i Lymphocyte- and type II interferon-mediated pathways were upregulated in the CD8 T cells between days 1 and 0 by GSEA analysis.

Back to article page