Fig. 5: Subchronic distribution and excretion of Pd-NPs in healthy wildtype and APCmin+ mice.
From: Biodistribution of nanoplastics in mice: advancing analytical techniques using metal-doped plastics
a XFI-maps showing the Pd-NPs in the feces droppings excreted over time in two wildtype mice. b Pd masses as measured by XFI and ICP-MS given as percentage of the daily dose per mouse as the excreted masses per time point (left) and the cumulative mass (right). ICP-MS and XFI measured the same samples. c Pd-NP recovery rates. ICP-MS measurements were recalculated for total organs (left) and summed up for total mouse (right) and given as % of daily dose. Data points represent individual measures, bars indicate mean values per group. d Tissue image of a kidney showing 104Pd, 105Pd, 106Pd, 108Pd, 110Pd in yellow and DNA in blue for ROI kidney194_1_1 (kidney from mouse #29194/wildtype). e IMC dual counts per pixel in brain and kidney showing 108Pd for 2 mice (1 = mouse #29194/wildtype, 2 = mouse #29207/APCmin+). The grey box between 0 and 1 dual counts indicates the noise range of the detector and only pixels above that area contain Pd. Respective ROI images are shown in Fig. S4.
