Fig. 2: Identification of fibroblast subtypes and cell communication networks. | Communications Biology

Fig. 2: Identification of fibroblast subtypes and cell communication networks.

From: Uncovering a fibroblast differentiation-based keloid classification by integration of single-cell and bulk RNA sequencing

Fig. 2

A UMAP dimensionality reduction reveals six distinct fibroblast subtypes across keloid and normal scar tissues. B Quantitative analysis of cell number and proportional distribution of fibroblast subtypes across samples. Fibroblast 3 is predominant in keloids, whereas Fibroblast 2 constitutes the major population in normal scars. C The Cleveland dot plot depicts expression of classical markers (ACTA2, COL1A1, TGFBI, TOP2A) in fibroblast subsets, with bar plots illustrating the proportional distribution of each cluster in keloid and normal scar samples. D Marker gene expression profiles highlight elevated ASPN, COMP, and POSTN expression in Fibroblast 3. E, F Cell communication between fibroblast subtypes. Fibroblast 3 engages in more extensive signaling interactions compared to other subtypes. KL keloid, NS normal skin, CC cell communication, UMAP Uniform Manifold Approximation and Projection.

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