Fig. 3: Pseudotime trajectory analysis and identification of DEFDRGs. | Communications Biology

Fig. 3: Pseudotime trajectory analysis and identification of DEFDRGs.

From: Uncovering a fibroblast differentiation-based keloid classification by integration of single-cell and bulk RNA sequencing

Fig. 3

A Pseudotime plot depicts the potential fibroblast differentiation sequence. B Identification of seven distinct differentiation states. C, D) Visualization of fibroblast subtypes mapped onto differentiation trajectories. E Expression of the top 100 fate-determining genes differentially expressed across differentiation states. F Schematic workflow for identifying DEFDRGs, defined by the overlap of fibroblast differentiation-associated DEGs and clinical diagnosis/time-related DEGs. DEFDRGs differentially expressed fibroblast-differentiation-related genes, DEGs differentially expressed genes.

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