Fig. 7: IHC validation in clinical samples and clinical phenotype correlation analysis. | Communications Biology

Fig. 7: IHC validation in clinical samples and clinical phenotype correlation analysis.

From: Uncovering a fibroblast differentiation-based keloid classification by integration of single-cell and bulk RNA sequencing

Fig. 7

A IHC staining depicts expression and semi-quantitative scoring of keloid subtype-specific markers in clinical keloid tissues (n = 3 independent samples per group; *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001; one-way ANOVA). Scale bars = 100 μm. Data are presented as mean ± SD. B–G Correlation analyses illustrate associations between keloid molecular subtypes and clinical phenotypic metrics: (B) VSS score, (C) lesion thickness, (D) tissue softness, (E) pain intensity, (F) itch severity, and (G) blood vessels. IHC immunohistochemistry, VSS Vancouver Scar Scale.

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