Fig. 1: CyTOF identifies Brain-associated leukocyte diversity in mice after SS2 infection. | Communications Biology

Fig. 1: CyTOF identifies Brain-associated leukocyte diversity in mice after SS2 infection.

From: A single-cell atlas of mouse central nervous system immune cells reveals unique infection-stage immune signatures during the progression of meningitis caused by Streptococcus suis

Fig. 1

A Schematic representation of the experimental design. B H-SNE embeddings of 4.8 × 106 immune cells derived from the female mouse brain (N = 20, each sample contains brains of six mice) at the overview level. Each dot represents a landmark, whose size is proportional to the number of cells it represents. Colors indicate the ArcSinh5-transformed expression value of each indicated marker. C H-SNE plots show cell densities. D H-SNE plots show the major immune lineage cluster partitions in different colors. E H-SNE map displaying all immune cells in each group from the brain of healthy and SS2-infected ICR mice analyzed by CyTOF. F Cell counts of each major immune lineage during SS2 infection. N = 4 in each group. Error bars represent the median ± SEM. A one-way ANOVA or Dunnett’s test was performed for analysis of multiple groups. P value < 0.05 (*); p < 0.01 (**); p < 0.001 (***); NS no significant difference.

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