Fig. 5: Characteristics of T cell phenotype changes during the progression of meningitis. | Communications Biology

Fig. 5: Characteristics of T cell phenotype changes during the progression of meningitis.

From: A single-cell atlas of mouse central nervous system immune cells reveals unique infection-stage immune signatures during the progression of meningitis caused by Streptococcus suis

Fig. 5

A Control and SS2 infected mouse brains and coronal sections at the leptomeninges and choroid plexus, stained for anti-CD3. Scale bar = 20 μm. Immunohistochemical images of CD3+ T cells in control and SS2-infected mice at different stages. Scale bar = 50 μm. B t-SNE maps showing the expression of specific marker molecules in T cells. C The t-SNE map shows the cluster partitions. D Phenotypic heatmap shows the phenotypic characteristics of the 13 clusters. E The cluster frequency heatmap shows their distribution and the Spearman clustering according to the cell proportion in each sample. F, G t-SNE maps showing the expression of specific marker molecules in T cells and the proportion of specific subgroups in T cells. N = 4. Error bars represent the median ± SEM. A one-way ANOVA or Dunnett’s test was performed for analysis of multiple groups. P value < 0.05 (*); p < 0.01 (**); p < 0.001 (***); NS no significant difference.

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