Table 1 Calculated IC50s of the identified hits from the high-throughput screen

From: Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling

Compound

IC50 ± SEM (µM) by fluorescence

IC50 ± SEM (µM) by LC-MS/MS

Captopril

0.0130 ± 0.002

0.006 ± 0.001

Thiorphan

2.360 ± 0.42

3.510 ± 0.37

D609

31.05 ± 10.82

44.90 ± 5.21

Raloxifene

102.24 ± 13.23

88.57 ± 3.12

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