Fig. 6: Cancer cells in contact with CAFs change the ECM composition to facilitate migration and avoid apoptosis. | Communications Biology

Fig. 6: Cancer cells in contact with CAFs change the ECM composition to facilitate migration and avoid apoptosis.

From: Cancer-associated fibroblasts shape the formation of budding cancer cells at the invasive front of human colorectal cancer

Fig. 6

Dot plots showing the “ECM Organization Score” (A), “Collagen ECM Score” (B), “Focal Adhesion Score” (C), “Apoptotic process Score” (D), and “miRNA Targets Score” (E). The dots represent mean values, and the error bars indicate standard deviation. FOVs are separated into high-density budding (HDB), mid-density budding (MDB), and low-density budding (LDB) areas. Blue dots correspond to the mean score of the budding cells that are in contact with CAFs, whereas light green dots correspond to the mean score of budding cells not in contact with CAFs. The box plots to the right show the mean values for the HDB, MDB, and LDB areas. Error bars indicate standard deviations.

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