Fig. 4: Social memory is impaired in NL3 R451C KI mouse model of autism. | Communications Biology

Fig. 4: Social memory is impaired in NL3 R451C KI mouse model of autism.

From: Social memory engram formation impairment in neuroligin-3 R451C knock-in mice is caused by disrupted prefrontal NMDA receptor-dependent potentiation

Fig. 4

A Top: Representative heatmaps of the three-chamber tests performed in the WT/KI mice. Bottom: The KI mice exhibited social novelty deficits, as analyzed by the three-chamber sociability (Left) and social novelty (Right) tests (Left: two-way ANOVA, Interaction: F(1, 32) = 3.982, p = 0.055; WT vs. KI: F(1, 32) = 0.247, p = 0.623; Empty vs. Stranger 1: F(1, 32) = 59.66, p < 0.0001; Right: two-way ANOVA, Interaction: F(1, 32) = 5.053, p = 0.032; WT vs. KI: F(1, 32) = 0.045, p = 0.834; Stranger 1 vs. Stranger 2: F(1, 32) = 12.71, p = 0.001). B Top: Representative heatmaps of the long-term social memory tests performed in the WT/KI mice. Bottom: The KI mice exhibited impaired long-term social memory (two-way ANOVA, Interaction: F(6, 112) = 1.015, p = 0.420; Time (day): F(6, 112) = 0.890, p = 0.505; WT vs. KI: F(1, 112) = 31.03, p < 0.0001).All data were mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. n = number of mice.

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