Fig. 3: Dynamic changes of ferroptosis related genes in astrocytes following Pb exposure. | Communications Biology

Fig. 3: Dynamic changes of ferroptosis related genes in astrocytes following Pb exposure.

From: Lead binds HIF-1α contributing to depression-like behaviour through modulating mitochondria-associated astrocyte ferroptosis

Fig. 3

A UMAP plot depicting the unsupervised astrocyte subpopulations in Control and MPb groups (n = 3); B Marker gene of astrocyte subpopulations following Pb exposure in astrocytes; C Proportion of astrocyte subpopulations in Control and MPb groups (n = 3); D The ferroptosis score of astrocyte subpopulations by AddModuleScore; E, F Pseudotime scores in differentiation state (cluster 3 to cluster 5 or 6) of astrocytes following Pb exposure from the lowest to the highest. G Results of pseudotime trajectory analysis are split by exposure status and coloured based on cluster of astrocytes (red, green, and blue are represented cluster 3, 5, and 6), respectively; H Expression dynamics of ferroptosis-related DEGs in pseudotime trajectory in differentiation state of astrocytes (left represents cluster 3 to 5; right represents cluster 3 to 6). *P < 0.05 vs Control; **P < 0.01 vs Control. Comparisons between the two groups are made using Student’s t-test.

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