Fig. 3: Cell line expression and drug response.

a Heatmap depicting the normalized expression levels of 29 selected lncRNAs and HRD- scores across ovarian cancer cell lines from the CCLE. Expression values were normalized across cell lines to allow comparison. b Pearson correlation coefficients between individual lncRNA expression levels and HRD scores across CCLE ovarian cancer cell lines are shown. c Top row: Scatter plot of HRD score versus ENSG00000254031.1 expression (left), and comparisons of ENSG00000254031.1 expression between HRD-high (HRD ≥ 52) vs HRD-low (middle) and BRCA1-mutated/methylated vs BRCA1-unaltered cell lines (right). Bottom row: Similar analyses for ENSG00000272172.1. Statistical comparisons were performed using Pearson correlation and two-tailed unpaired t-tests. d Expression profiles of four representative lncRNAs across ovarian cancer cell lines stratified by histological subtype (mucinous, high-grade serous, endometrioid, clear cell). Differences were assessed using multi-way ANOVA to account for subtype-specific variance. e Pearson correlation plots showing HRD scores versus expression of ENSG00000231966.1 (top) and ENSG00000250271.1 (bottom) specifically in HGSC cell lines. f Correlation matrix showing Pearson correlation coefficients between the IC50 values of five PARP inhibitors and expression of the 29 lncRNAs. Statistically significant correlations (p < 0.05) are marked with an asterisk. g Heatmap illustrating relative expression of selected lncRNAs across seven ovarian cancer cell lines and three immortalized fallopian tube epithelial cell lines, as measured by real-time qPCR. Expression was normalized to GAPDH and represented as fold change. h Bar plots comparing expression levels of selected lncRNAs between immortalized fallopian tube epithelial cell lines and ovarian cancer cell lines, as measured by real-time qPCR. Data shown represent one biological replicate of three independent experiments. Statistical significance was assessed using unpaired two-tailed t-tests; differences with p values < 0.05 were considered significant.