Fig. 2: Molecular mediators of hypothermic signaling.
From: Molecular mediators of cold adaptation in mammalian cells

Molecular mediators of hypothermic signaling includes (i). TRPM8 ion channel (ii). β-Adrenergic receptor induced regulation of UCP1 (iii). Epigenetic modifications (iv). RNA-binding proteins (RBM3 and CIRBP).