Fig. 4: Epigenetic clock index vs. clinicopathological variables.
From: Mapping the temporal landscape of breast cancer using epigenetic entropy
The distribution of epigenetic clock index values (cβ) among invasive ductal carcinomas in the Lund and TCGA cohorts, by (A, B) molecular subtype as predicted by the PAM50 algorithm; (C, D) fraction of genome altered (FGA) by copy number alterations; (E) tumor grade; (F) tumor stage; (G) tumor size; and (H) T-stage. Pairwise comparisons of medians in panels A, B, E, F, and H were performed using a two-sided Wilcoxon rank-sum test (*P < 0.05, **P < 0.01, ***P < 0.001). In panels C, D, and G, regression lines and bootstrapped 95% confidence intervals are shown; Pearson correlations (R) are indicated. Boxplots in A, B, E, F, H, display: center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; points, outliers.
