Fig. 6: Pathway enrichment and immune decomposition analyses.
From: Mapping the temporal landscape of breast cancer using epigenetic entropy
A A gene set enrichment analysis (GSEA) was performed for the epigenetic clock index \({c}_{\beta }\). Pathways with a positive (negative) enrichment score are enriched in mitotically older (younger) tumors. Only pathways with a false discovery rate (FDR) below 0.1 are shown; *FDR < .05; **FDR < .01; ***FDR < .001; ***FDR < .0001. B Epigenetic clock index vs. the extent of immune infiltration (absolute immune score) as estimated by CIBERSORTx. C The immune compartment of each tumor was decomposed using CIBERSORTx; the compartment fractions are shown for tumors of similar mitotic age (epigenetic clock index \({c}_{\beta }\)). Boxplots display: center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; points, outliers.
