Fig. 2: Localizations of lamins during metaphase.
From: Mitotic dynamics of the nuclear lamina behind the scenes of chromosome separation
During metaphase, B-type lamins are able to form a matrix-like network in a RanGTP- and Dynein-dependent manner. In addition, LAP2α influences the localization of B-type lamins towards the spindle. A fraction of B-type lamins is also detected diffusely in the nucleoplasm. The localization of A-type lamin during metaphase is less clear. While one study shows that lamin A also localizes at the spindle in a dynein-dependent manner and is associated with BAF and LAP2α, other studies have shown that A-type lamins are soluble and homogeneously distributed in the nucleoplasm during metaphase36,60,76. Figure created with BioRender.com.
