Table 1 Phosphorylation of Lamins During Mitosis Drives Their Depolymerization
From: Mitotic dynamics of the nuclear lamina behind the scenes of chromosome separation
Lamin type | Residue | Kinase | Reference | Mitosis phase | Consequence |
|---|---|---|---|---|---|
Lamin B1 | Ser23 | CDK1 | Residue positions in UniProtKB P20700 | Prophase to pro-metaphase | Disrupt lamin monomer head-to-tail interactions |
Ser393 | |||||
Ser395 | PKC | 42, 49 | |||
Ser405 | |||||
Lamin B2 | Thr34 | CDK1 | Residue positions in UniProtKB Q03252 | ||
Ser37 | |||||
Ser405 | |||||
N/A | PKC | 48 | |||
Lamin A/C | Thr19 | CDK1 | 45–47 | ||
Ser22 | |||||
Ser390 | |||||
Ser392 | |||||
Tyr45 | Src | 57 |
