Fig. 6: Brain connectivity training effects: increased LOC-OP connectivity after training.

A–C Change in LD connectivity (post-training minus pre-training) in connections of clusters 1–3. Error bars show the standard error of the mean in each group. D Interaction plot of the Group x Time (pre-, post-training) effect (ANOVA) for the LOC-OP connection (lateral occipital cortex – occipital pole) (n = 53). We found a significant training-induced increase in task-based connectivity from the LOC to the OP. Boxes show the median (center line) and interquartile range (IQR); whiskers extend to 1.5 × IQR; gray points are individual participants. Overlaid black markers/lines are marginal means with 95% confidence intervals (control n = 27, training n = 26). *p < 0.05 p-FDR corrected. PRC perirhinal cortex, EC entorhinal cortex, HIPP hippocampus, LOC lateral occipital cortex, OP occipital pole, SFG superior frontal gyrus, IFG inferior frontal gyrus, tri triangularis, oper opercularis. The color of the ROIs’ names denote whether they are a visual (green), MTL (gold), or PFC (black) area.