Fig. 4: ATM inhibition enhanced the knock-in efficiency with linearized DNA, regardless of the strand type. | Communications Biology

Fig. 4: ATM inhibition enhanced the knock-in efficiency with linearized DNA, regardless of the strand type.

From: ATM Inhibition Enhances Knock-in Efficiency by Suppressing AAV-Induced Activation of Apoptotic Pathways

Fig. 4

Genome editing using a self-complementally AAV (scAAV), b linearized single-stranded DNA (ssDNA), c linearized double-stranded DNA (dsDNA), or d plasmid donor vector with HITI following ATM inhibitor treatment (10 nM AZD1390). Data are presented as mean ± SD. (n = 3 independent replicates). Unpaired t-tests were conducted.

Back to article page