Table 3 In vitro antimalarial activities of 22 (determined by [3H]-hypoxanthine incorporation; data from 2–3 independent experiments)

From: Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites

Compound

IC50 (nM)a

Resistance indexb

NF54

K1

TM90-C2B

RI1

RI2

Artesunate

1.3

0.58

1.1

0.45

0.85

Chloroquine

3.6

60

58

16.67

16.11

Atovaquone

0.14

0.20

11,536

1.4

82,400

22

0.53

0.56

111.9

1.06

211.13

  1. aPf NF54: CQ sensitive; K1: CQ, pyrimethamine, mefloquine, cycloguanil resistant; TM90-C2B: atovaquone resistant
  2. bRI1 = IC50 K1/IC50NF54, RI2 = IC50 TM90-C2B/IC50NF54
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